By Florencio Zaragoza Dörwald
So much syntheses within the chemical examine laboratory fail and customarily require a number of makes an attempt prior to continuing satisfactorily. Failed syntheses will not be purely discouraging and troublesome, but additionally fee loads of time and cash. Many disasters may perhaps, even if, be shunned by way of realizing the structure-reactivity dating of natural compounds.
This textbook highlights the competing procedures and obstacles of an important reactions utilized in natural synthesis. by means of permitting chemists to quick realize capability difficulties this e-book can assist to enhance their potency and success-rate. A needs to for each graduate pupil but in addition for each chemist in and academia.
1 natural Synthesis: common Remarks
2 Stereoelectronic results and Reactivity
three the steadiness of natural Compounds
four Aliphatic Nucleophilic Substitutions: problematical Electrophiles
five The Alkylation of Carbanions
6 The Alkylation of Heteroatoms
7 The Acylation of Heteroatoms
eight Palladium-Catalyzed C-C Bond Formation
10 Monofunctionalization of Symmetric Difunctional Substrates
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